Objective: To find out the effectiveness of mulligan mobilization with muscle energy technique and sensory targeted ankle rehabilitation strategies with lateral ankle sprain.

Methods: Male subjects (18-26 year) were divided into two groups based on the random sampling method and selection criteria (n=50) (group A and group B). Group A included 25 athletes who received mulligan mobilization with muscle energy technique for three days per week for two weeks. Group B included 25 athletes who received sensory targeted ankle rehabilitation for two days per week for 2 weeks. The outcome measures used in this study included the numerical pain rating scale for assessing the pain, weight bearing lunge test, goniometer for ankle dorsiflexion range of motion. Prior to the treatment period, and then 3rd weeks into the intervention, both group A and groups B underwent testing.

Results: The study’s findings demonstrated that mulligan mobilization with muscle energy technique, are significantly more effective than sensory targeted ankle rehabilitation in their influence on the process of ankle sprain rehabilitation on a chosen criteria variable.

Conclusion: From the findings of the study, It has been concluded that 2 week of mulligan mobilization and muscle energy technique is more effective in improving the range of motion and decreasing pain on sub-acute lateral ankle sprains. The facilitation to enhance male athletes' ankle ROM which improves the range and sport performance and make them recover fast from injuries. Hence it is recommended to implement mulligan mobilization and muscle energy techniques in the early rehabilitation phase which decreases joint stiffness and muscle wasting and produces a quick rehabilitation period.