The study was to examine the isolated and combined plyometric exercises and agility drills on kho-kho game performance among college level men kho kho players. Total N=48 (forty eighty) men college level men kho kho players recruited randomly from various college of Andhra Pradesh and their age period ranged from 18 years to 25 years as per subject’s school records and, who at least participated college level kho kho games competitions. The chosen kho kho players was randomly recruited into four groups each group n=12 kho 2kho players i.e. empirical groups I kho kho players underwent isolated plyometric exercises (PEG) = 12), empirical group II kho kho players underwent isolated agility training (ATG = 12), empirical group III underwent combined plyometric exercises and agility training (CTG = 12) and control group kho kho players (NTG = 12). NTG was practiced only their respective specialization game. The training period was fixed for 18- week’s duration and four sessions in a week. The measurement of kho kho technical skill scores was collected through three coaches Judgment rated scale in numbers Rating scale 1 to 10 points before and after the completion of specific training. The collected score’s were analyzed through ANCOVA and level of significant was restricted at 0.05 levels. The study found that isolated, combined plyometric exercises and agility drills program had positive significant impact in improving kho kho game performance of kho kho players of three empirical group’s players comparative to control group.