The purpose of the study was to evaluate the fundamental motor skills in children and young adult with Moderate Mental Retardation (MR). The present study also assessed the differences between boys and girls and among different age groups. The objective of the study was to determine the seven loco motor skills such as walking, running, jumping, throwing, kicking, agility and balance of moderate MR children and young adult with different age groups. Participants were n=90 students (45 boys and 45 girls) with moderate MR aged from 9 to 15 years old. The subjects attended special schools from St. Annes Convent and St. Bishop Sargent School for Mentally Retarded Children, Tirunelveli. Subjects were divided in three age groups (9-11, 12-13 & 14-15 years old). The Test of Gross Motor Development (TGMD, Ulrich, 1985) ^[10] was used for the assessment of the fundamental motor skills. The TGMD examines seven loco motor skills. Descriptive statistics and the two- way factorial (2x3) Analysis of variance (ANOVA) was used to evaluate the influence of the two categories of variables on the dependent variables. If the obtained ‘F’ ratio for interaction was significant, then the simple effect test was used to find out which of the mean performance score for gender and age groups were significant. The individual comparisons were made for the interpretations using the scheffes’s test. The results indicated that there was a significant difference among age groups in the performance of fundamental motor skills for children and young adult boys and girls with moderate MR. Hence it is recommended that, adapted physical educators should emphasize in a special designed adapted physical education program towards the development of fundamental motor skills for the children with moderate mental retardation.