Objectives: This study aims to establish a multidimensional analytical framework regarding the prevalence of football injuries at Saigon University (SGU) and to identify specific pathomechanisms related to the interaction between intrinsic factors (physical fitness, anatomy) and extrinsic factors (artificial turf, tropical climate).

Methods: The study employed a literature review combined with secondary data analysis from internal medical reports, anthropometric studies on SGU male students, and environmental monitoring data in Ho Chi Minh City. Injury mechanisms were cross-referenced with modern biomechanical models and FIFA sports medicine guidelines.

Results: Data indicates that injury rates are predominantly concentrated in the lower extremities, specifically the ankle (16.2–39.3%) and knee joint (10.8–24.9%). The root causes were identified as a convergence of three factors: The "Weekend Warrior" syndrome and Gluteal Amnesia; Discrepancies in shoe-surface interaction on artificial turf; and The impact of Heat Stress and PM2.5 particulate matter leading to impaired neuromuscular control.