Background: Injuries in Physical Education (PE) at universities not only impair health but also negatively affect students' psychology and academic performance. At Hanoi Metropolitan University (HNMU), the increasing intensity of elective modules such as Football and Volleyball necessitates a scientific injury prevention protocol.

Methods: The study was conducted in two phases: (1) A survey of injury status among 450 students; (2) A pedagogical experiment on 160 students using the "HNMU-Safe" warm-up protocol modified from the FIFA 11+ program combined with awareness education on R.I.C.E. first aid techniques.

Objectives: To identify common types of injuries and evaluate the effectiveness of a specialized prevention protocol in minimizing risks during PE classes.

Results: The survey phase recorded a cumulative injury rate of 32.4%, with ankle sprains and knee injuries accounting for the highest proportions. Following the intervention, the experimental group (EG) saw a reduction in injury rates to 8.75%, compared to 28.75% in the control group (CG). Chi-square testing indicated a highly significant statistical difference (χ2 = 10.45; p < 0.01). The average recovery time decreased from 4.6 days to 3.2 days.