This study investigates the influence of digital technologies on students’ physical activity participation in Vietnamese universities. A quantitative research approach was employed, and data were collected from 452 university students through a structured questionnaire. The study examined the relationships among Digital Technology Usage (DTU), Motivation for Physical Activity (MOT), and Physical Activity Participation (PAP). Data were analyzed using SPSS and SmartPLS. The results revealed that digital technology usage significantly and positively influences both students’ motivation for physical activity and their participation in physical activity. Motivation was also found to have a significant positive effect on physical activity participation and partially mediated the relationship between digital technology usage and physical activity participation. The findings suggest that digital technologies, including fitness applications, wearable devices, online exercise platforms, and social media, play an important role in encouraging active lifestyles among university students. The study provides practical implications for universities and policymakers in developing technology-enhanced strategies to promote physical activity and improve student health in the context of digital transformation.